1. NRへの変換: 最初のステップとして、摂取されたNMNはニコチンアミドリボシドキナーゼ（NRK）という酵素によってNRへと変換されます。この反応により、NMNはNRに転換され、その後の代謝プロセスに進みます。 2. NRの変換: NRはさらにニコチンアミドリボシドキナーゼによってNAM（ニコチンアミド）としてリン酸化されます。そして、NAMはニコチン酸モノヌクレオチドアデニルトランスフェラーゼ（NMNAT）と呼ばれる別の酵素によってNAD+へと変換されます NMN。これにより、NR経由でNAD+が生成される経路が存在します。 3. NMNとNRの比較: NMNとNRはいずれもNAD+の前駆体として機能しますが、その変換経路が異なります。NMNはNRを介さずに直接NAD+へと変換される一方で、NRはNRKを介してNAMを経由してNAD+へ変換されます。この違いにより、NMNとNRの効果や代謝経路に関する研究が行われています。 4. 代謝経路の意義: NMNおよびNRを介したNAD+の合成経路は、体内でのNAD+の調節や供給を支える重要なプロセスです。これにより、細胞内のエネルギー生成や代謝、DNA修復、細胞機能の維持などが適切に行われることが保証されます。この代謝経路が正常に機能することは、健康の維持や老化の遅延に貢献する可能性があります。 総括すると、NMNはNAD+に変換される際に、NRを介して段階的な変換が行われます。これにより、細胞内の重要なプロセスを支えるNAD+の供給が確保され、健康維持や老化の影響に関する研究が進行中です。
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